[专家风采]
胡以平

个人简介:

      胡以平  男,复旦大学博士,美国Roswell Park Cancer Institute博士后。曾任美国耶鲁大学医学院免疫学系副研究员,现任第二军医大学细胞生物学教研室主任、第二军医大学转基因动物研究室主任及全军分子遗传学开放实验室副主任,并为中国科学院上海生命科学研究院干细胞生物学中心客座研究员。
      目前的研究方向是肝干细胞的生物医学问题研究。最初于1996年开始肝干细胞方面的工作,迄今完成的工作主要有:1)采用活体移植实验,证明了成体肝脏中肝干细胞的存在(Chinese Science Bulletin 47(3): 211-213, 2002);2)从Retrosine处理小鼠的肝脏中分离培养了肝干细胞系,证明了这种细胞具有肝向和胆向分化的潜能,以及再殖(repopulate)损伤肝脏的能力,并意识到了其肝向分化的启动具有“开关”效应(Stem Cells 24(2):322-332, 2006);3)采用基因芯片等方法,分析了该细胞在肝向分化过程中的表达谱,发现了一些干性维持和分化相关基因(Front Biosci 12:1691-1698, 2007;J Cell Biochem ;106(1):16-24,2009);4)建立了来源于人早期胚胎肝芽(liver bud)的肝干细胞系,并从发育生物学角度证明了该细胞的生物学特性处于内胚层细胞向肝和胰方向分化的“三叉路口”。同时,在肝干细胞研究所需的基因工程小鼠模型的产生方面也有一些工作。  近5年发表的主要出版物有:

1. Xin-Rong Tao, Wen-lin Li, Juan Su, Cai-xia Jin, Xin-min Wang, Jian-xiu Li, Jun-kai Hu, Zhen-Hua Xiang, Joseph T. Y. Lau and Yi-Ping Hu: Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice. Journal of Cellular Biochemistry 108(3):693-704,2009

2.Wang Q, Li WL, You P, Su J, Zhu MH, Xie DF, Zhu HY, He ZY, Li JX, Ding XY, Wang X, Hu YP. Oncoprotein BMI-1 induces the malignant transformation of HaCaT cells. J Cell Biochem ;106(1):16-24,2009

3.Xinghua Pan, Alexander Eckehart Urban, Dean Palejev, Fabian Grubert, Yiping Hu, Michael Snyder, Sherman M. Weissman: New procedure for highly specific, hypersensitive and unbiased whole genome amplification. Proc Natl Acad Sci U S A  105(40):15499-504, 2008

4.Jin CX, Li WL, Xu F, Geng ZH, He ZY, Su J, Tao XR, Ding XY, Wang X, Hu YP. Conversion of immortal liver progenitor cells into pancreatic endocrine progenitor cells by persistent expression of Pdx-1. J Cell Biochem  104: 224-236, 2008(封面论文)

5.Jin C, Li W, Xu F, Zhu J, He Z, Hu Y. Blocking SCF/c-Kit signal did not inhibit the proliferation of cultured liver progenitor cells. IUBMB Life 59(7):458-64, 2007

6.Wenlin Li, Pu You, Qing Wei, Yao Li, Xuping Fu, Xiaoyan Ding, Xin Wang, Yiping Hu. Hepatic differentiation and transcriptional profile of the mouse liver epithelial progenitor cells (LEPCs) under the induction of sodium butyrate. Front Biosci 12:1691-8, 2007.

7.Zi XY, Yao YC, Zhu HY, Xiong J, Wu XJ, Zhang SZ, Ba Y, Li WL, Wang XM, Li JX, Yu HY, Ye XT, Lau JTY and Hu YP. Long-term Persistence of Hepatitis B Surface Antigen and Antibody Induced by DNA-mediated Immunization Results in Liver and Kidney Lesions in Mice. Eur J Immunol  36(4):875-86  2006

8.Li WL, Su J, Yao YC, Tao XR, Yan YB, Yu HY, Wang XM, Li JX, Yang YJ, Lau JTY and Hu YP. Isolation and Characterization of Bipotent Liver Progenitor Cells from Adult Mouse. Stem Cells  24 (2): 322-32 2006 (首届中国百篇最具影响优秀国际学术论文,2006年)

9.Zi XY, Yao YC, Zhu HY, Xiong J, Wu XJ, Zhang SZ, Ba Y, Li WL, Wang XM, Li JX, Yu HY, Ye XT, Lau JTY and Hu YP. Long-term Persistence of Hepatitis B Surface Antigen and Antibody Induced by DNA-mediated Immunization Results in Liver and Kidney Lesions in Mice. Eur J Immunol 36(4):875-886, 2006.(被加注热点评论:Commentary article:Hanke T. On DNA vaccines and prolonged expression of immunogens. Eur J Immunol 36(4):806-809, 2006 )

10.Xin Wang, Yiping Hu, Zongyu Chen and Xiaoyan Ding: Liver Stem Cells in Regenerative Medicine in STEM CELLS AND REGENERATIVE MEDICINE edited by Walter Low (University of Minnesota, USA) & Catherine M Verfaillie (University of Minnesota, USA & Catholic University of Leuven, Belgium) , World Science Publishing, ISBN 978-981-277-576-4 and 981-277-576-5, 2008

 

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